News


  • January 1st, 2007 :
    "Laboratoire PAREVA" becomes a self-governing compagny, but still 100% subsidiary of MAREVA

    July 19th, 2007 :
    "Laboratoire PAREVA" sent its dossier for PHMB to Repporter Member State to comply with Direction 98/8/EC on biocides (BPD)

Additional information

Biocidal action of PHMB

Image
ImagePHMB action on micro-organisms

 

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A simple description of the mechanism of action of PHMB against bacteria is as follows :
1. PHMB is quickly attracted to the bacteria surface
2. PHMB neutralises the cell wall protection system (called « exclusion system») : it combines with proteins in charge of this defence
3. PHMB passes through the cell wall to join the cytoplasmic membrane
4. PHMB enters in the 1st stage of its action against bacteria (bacteriostatic level : reversible) :
PHMB creates some spaces in the cytoplasmic membrane by association with proteins. This starts up the loss of little size compounds (potassium, calcium…) : membrane is getting permeable
5. PHMB enter in the 2nd stage of its action against bacteria (bactericidal level : not reversible) :
PHMB breaks up the cell cytoplasmic membrane. The cell looses its vital compounds
6. The cell dies

ImageSome efficacy data

These data are given as an information.
One should perform its own tests prior to declare any efficacy data of end use developed products.

Micro-organisms Indicative M.I.C. values (ppm)
Bacteria  
Pseudomonas aeruginosa 100 (*)
Staphylococcus aureus 1
Streptococcus faecalis 25
Escherichia coli 25
Pseudomones putida 25
Klebsiella aerogenes 25

 

Fungii Indicative M.I.C. values (ppm)
Aspergillus niger 750
Trichophyton mentagrophytes 25

 

Yeasts Indicative M.I.C. values (ppm)
Endomycopsis albicans. 300

 

(*) Decreasing of pseudomonas aeruginosa versus concentrations and contact times :

Contact times 5 min. 15 min. 30 min.
with PHMB at 10 ppm - 75 % - 88 % - 99.999 %

 

Contact times 30 seconds 1 min. 3 min.
with PHMB at 50 ppm - 82 % - 96 % - 99.999 %